Symbol
Name
ID

Itgb3
integrin beta 3
MGI:96612

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgA level	Increased circulating IgE level	Leukocytosis	Acute myeloid leukemia	Eczematoid dermatitis	Platelet antibody positive	Asthma
Disease(s) Associated with ITGB3	Increased circulating IgA level	Increased circulating IgE level	Leukocytosis	Acute myeloid leukemia	Eczematoid dermatitis	Platelet antibody positive	Asthma
acute myeloid leukemia
asthma
autoimmune thrombocytopenic purpura
thrombocytopenia

Mouse Phenotypes

immune system phenotype

abnormal osteoclast differentiation

impaired macrophage chemotaxis

enlarged spleen

decreased macrophage cell number

decreased osteoclast cell number

increased osteoclast cell number

increased monocyte cell number

abnormal osteoclast morphology

increased IgG level

abnormal macrophage physiology

abnormal osteoclast physiology

myositis

dermatitis

Availability

Mouse Genotype

Itgb3^tm1Hyn/Itgb3^tm1Hyn

Itgb3^tm1Hyn/Itgb3^tm1.1Wlbcr
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Itgb3^tm1Hyn/Itgb3^tm1.1Wlbcr
Tg(Pf4-icre)Q3Rsko/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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